During her academic and professional career in Turkey between 2003 and 2018, she worked as an Assistant professor at the Department of International Relations, Faculty of Economics and Administrative Sciences at the Istanbul Kültür University, where she also later held the position of Vice-chair of the department and lectured primarily on the International Public Law, Human Rights Law and History of Political Thought. Currently, Dr Tiryaki is a full faculty member at  the Department of International and European Law of the Pan-European University’s Faculty of Law, where she lectures mainly on Human Rights Law, Diplomacy, and Foreign Policy. In addition, she regularly lectures on Human Rights, International Public Law, and Current Issues in the Middle East at the Bratislava International School of Liberal Arts (BISLA). Dr Tiryaki has published and edited books on related topics. Her work has been published in various national and international academic journals and newspapers. She has lectured, delivered speeches, and contributed to the discourse at different platforms including United Nations, European Parliament, Wilton Park Conference, LSE, Brookings Institute, Carnegie Endowment for International Peace, GMF, EuroMeSCo, The Bosphorus Conferences, and many others. 

In addition to her academic work, Dr Tiryaki utilises her expertise as an active member of civil society. She worked as a senior research fellow and project coordinator for the leading Turkish think tank (founded in 1994), Turkish Economic and Social Studies Foundation (TESEV) between 2003 and 2008. Her work for the organization contributed to the final version of the Annan Plan for reunification of Cyprus. Later, she moved from TESEV to the Global Political Trends Center (GPoT Center) in Istanbul, which she co-founded in 2008, and served as deputy director until 2018. She was a regular columnist for the Turkish Daily News (Hürriyet Daily News) from 2006-2009.

As an expert on the politics of the Middle East and Turkey, she was an advisor for the Slovak Minister for Foreign Affairs. During that time, working at the Office of the Minister, she prepared complex foreign policy and security analyses on given topics. Currently, she is collaborating with GPoT Center as an Associate Fellow and with GLOBSEC as Associate Fellow for the Middle East. In 2021, she became the Chairwoman of the Helsinki Committee for Human Rights in Slovakia, where she promotes security and education about human rights. Dr Tiryaki is a member of SAK (Slovak Bar Association), ILA (International Law Association), RUSI (The Royal United Services Institute),  BIAA (The British Institute at Ankara), MESA (The Middle East Studies Association), IPSA (International Political Science Association), APSA (American Political Science Association), UİK-IRCT (The International Relations Council of Turkey) and networks like DARE and  EUROMESCO. Furthermore, she worked as an advisor for the World Handicapped Foundation and was a board member of World Disability Union and Human Security Collective.